Manny,

The load for my .50 was 115 gr of 2F Goex Express with a 718 gr Brooks Creedmoor or a 680 gr PP.
My Shiloh has the 1/22 ROT. I only used it once up in the Michigan UP and took a Whitetail Buck with it. It pushed him sideways over a small brook. The shot was a little high that went through both shoulder blades and spine. My favorite hunting rifles were the .44's. .44-90BN and the .44-77. Took three bison with them in fine shape and never recovered a bullet.
Just before Bill left us he wanted a .44-77.

I sort of retired Calamity. Heavy recoil tore the retina in both eyes a couple years ago and I lost a lot of my center vision.
I guess the 82 years are making me a little wimpy, but I still shoot it on and off to keep the bore shiny. laugh

You guys stay well.

Kurt