the 22-250AI with a 70 grain TSX bullet seems to be bordering on a .243Win with the 85 grain TSX! That is sure an interesting idea! Too bad most all manufactururers seem to want to put 1-14's in their 22-250's leading one to a custom rifle. The place I have seen problems with the 30-06 is shooting a small whitetail with a somewhat harder 180 grain bullet. It looks like from the discussions that a .223 with a 62 grain TSX will probably outperform a 30-06 with a 180 on a small deer under 100 yards, but probably not a 30-06 shooting a 150. For a low recoil type rifle the 22-250 with a 62 grain TSX with the right twist seems to be very interesting!
Just spoke briefly with my friend at the gun store I frequent, they lost two bucks in Alabama this year shooting them with that new Rem 6.8SPC, don't know the details, he usually shoots a .260 and as far as I know has never lost one with that rifle.