No experience.
BUT - the 6.5 X 55 - with the right bullets is a cartridge that has amassed quite a reputation on moose.
And compared to a moose - a grizzly is easy to kill. Even a caribou carcass that weighs the same as a grizzly has way tougher bones. Bears aren't built all that sturdily.
I'd feel well armed with a good 6.5 - anywhere in B.C. - for defense against anything. Not that it would be my first choice for hunting a grizzly, as I shoot my 375H&H very accurately and with ease.