Agreed on Drop Right the [bleep] Now shots. When they do that I'm always ready to throw another one in them. I feel much better if they take 2 steps and drop.
Those have started worrying me a bit too over the years. I put another in and get ready to a second dose.
To answer the original question, with a firearm I aim for the exit even if it means hitting a shoulder on the way in or out. With archery gear, I do tend to stay clear of the shoulder and if the angle isn't right, I don't shoot. I've "mentored" a few new hunters and one thing I stress is that that the so called perfect broadside shot is pretty much a fantasy. Pretty much alwasy (at least in my limited experience) deer are at some kind of angle to you no matter how slight. Aim accordingly.