Having killed deer with everything from .22 rimfires to .30-06's and 12 gauge slugs, I absolutely don't "expect" them to drop instantly from lung shots with anything. On the other hand, there's not a bit of doubt that I've gotten a higher percentage of instant drops with the faster smallbore's using bullets that tend toward rapid expansion/fragmentation than with the bigger, slower, more stoutly constructed projectiles. What's more "expected" {by me at least} is for a lung shot deer to run 40-60 yards before falling over, regardless of what they've been shot with. Some a bit less, and some more of course, but barring the rare extremes, the 40-60 dash is the norm and I haven't found that to vary to any significant degree regardless of whether they were poked with a 50 gr bullet from a .222, a 180 from a .30-06 or a 500+ gr. 12 gauge slug..