Yes they will work, No I won't use one unless it is all I had.
I have witnessed/killed elk with 243, 270, 7mmRM, 30-06, 300WM, 338-06, 338WM, 375 H&H. I personally shoot a 338-06. There is no substitute for bullet diameter.
The elk I have witnessed with 338 and up calibers left no doubt that they were hit.
The smaller calibers worked, but I prefer the bigger calibers.
Sorry, no personal experience with the 25's.
