I can vouch for the fact that .30-06 150's will come apart on the shoulder of a Bull moose
Probably have better results with a 180.
but the 220 will punch clean through a Cow Moose. I still had to wait for the Moose to die when I got up to it. I shot a very large Bull with the 350 grain Interlock out of a .450 Marlin and he was dead by the time I could get to him. That's the only time I ever seen a Moose die that quick.
Slow death is typical with moose. I once shot a small bull twice with a 375Mag. Both perfect lung shots broadside. He just stood there with no reaction to the hits and started to walk off. Another shot downed him. This same experience was repeated on another moose 4yrs later, but I just waited w/o shooting again. It to died slow. The only moose I have killed on the spot was another bull that caught a 35cal Speer 250gr behind the ear at 25yds. Tossed him to the ground. No walking away, no twitching.
