In 31 years of hunting in Colorado, I've shot one of my 22 Elk over 300 yards. That one was shot while I was standing next to a tree and I had the time to use that tree as a rest. I do have my rifle scope zeroed in at 300 yards but that is because there is only a 3" difference between 100 yards and 350 yards. So I don't have to think about anything except placing the shot where I want it. Over 300 yards and I will try to get closer. I would rather let them walk away before taking the chance of wounding them. But as others have said, most of my elk have been taken at under 200 yards with around 3 to 5 seconds to make the shot.
Good luck with your hunt.
