I don't hunt nearly as much as many on this forum, but I've shot a couple of Colorado bulls using the 168 TSX BT in a .308. Worked very well with a 200 yard zero at ranges of 266 and 319 yards, even if muzzle velocity was only about 2,700 fps.

Using a Bog-Pod and holding a little below the backbone in the 300 yard realm is not a particularly difficult job.