Jeff: They all kill;which one you like best is the one to use.I can only carry one at a time,and having a theoretically perfect rifle for every micro-niche in big game hunting is something I want to avoid.300's and 338's both cut the same swath.The 375 is a tad different than either.
The newer bullets are a help,but whatever advantage a 338 may gain by newer technology applies to the the 375 as well, and the 416, etc, up the line, so the bigger hammer still wins.Better bullets do seem to let you "stretch" a cartridge, so are always a great idea, on anything,and in any calber.
