I dunno. South TX buck, 225 pounds dressed... 300 wtby, 180 partitions, about 125ish yards. Neck shot was all I had. Neck was 26-27 inch girth. Centered neck, bullet blew up and was lodged against spinal column on this side of deer. Never would have died as I missed the arteries/veins. But was paralyzed so I could shoot him again.
I still don't hesistate to use small rounds though.... small 6mm accounted for all my meat last fall(except one shot with a 50 beowulf and one shot with a 50 bmg) and did just fine with 85 tsx in south TX.....
Take your pick, generally they say shot placement is it. And it is, I just expected a pass through with that combo.
Jeff