Just fine with the right bullets, etc.

I admittedly have a bias towards .30 cal on up for elk and bears. If you don't break them down with the shot, I REALLY like big obvious blood trails to follow and that is really the ONLY beef I have with smaller calibers on elk or bear where the thick hide and/or fat under it can plug a smaller hole.

If you place your shots in the shoulders or CNS with anything reasonable, there isn't going to be much difference between a 270 WSM and a .460 Wby Mag.

Granted they aren't going to go too far on a double lung shot either, but again a little extra blood on the trail gives me the warm and fuzzys.