With the modern ballistic drop compensation scopes like a Leupold Boone & Crockett reticle for example, they can be set to drop the bullet right in at 400, 450, or 500 yards. So the advantage of higher velocity for flat shooting is not as important as it used to be! In fact this scope has a special setting for the slower game bullets like a 180 30-06.

If you are worried about the sharp recoil of a 300 win mag vs a milder 30-06 you could split the difference in recoil and shoot a 180 300 WSM. Happy Hunting