On all sorts of game I have recovered only two tsx bullets, and never lost an animal to them. I have used Hornady interlocks before that with good success, but as Jorge says, they are a second best choice. Remington core locks have been used by me for years at moderate velocities with success, but once I switched to tsx, I have only used them for paper punching. When developing loads for my 375, I have started with the tsx and solid flat nose barnes right from the start. I may reload some cup and core for trigger time, but have not yet purchased any components.
I respect those opinions that differ from mine, but have formed my own from experience with many different cartridges, an am confident.
Randy