As far as the weight when speaking for the 375, With about well over 50 buffalo taken with them now in the last several years, the 270's have been the better choice. The 300's work great, but the additional 300fps for the 270's trumps the 30 grains advantage of the 300's. The penetration is usually better with the 270's, and they open more complete. There is something to be said for that extra 300fps with that 270gr chunk of solid copper.
And the bigger 375s like 375 Wby and 375 RUM will give those velocities with the 300s and a 378 would do it with 350 Barnes
