I have one instance, out of 56 elk I've shot, where I'm 80% sure the 338 killed an elk when a 7-08 likely wouldnt have.
Thought I could squeeze a shot between some trees and hit the tree an elk was standing about 10 feet behind.
The .338 250 grain partition went through the lodgepole, busted a shoulder and exited. Dumped the elk right there.