I�ve used a bunch of rifles on plains game chambered for a variety of cartridges. The smallest round was a .22-250 belonging to one of my PH�s, used for some culling, the but the smallest I�ve brought was a 7x57 and the largest a .375 H&H. They both worked well when a bullet that penetrated sufficiently (and all did) was put in the right place, as did every cartridge in between.
As I recall, all those cartridges have worked on deer too!
