No. I've seen animals shot with that combination from pronghorns at 300+ yards to a 6x6 bull elk at 100. However, the elk was shot broadside, closely behind the shoulder bones, so the bullet only hit flesh and ribs. It exited, leaving a pretty good-sized hole--which was not needed because the bull took off down the mountainside and soon ran head-on into a big conifer, obviously dead on its feet.
