I mostly use the 223 for coyote hunting, as it's all you need, and the variety of rifles and bullets for it are practically endless. I also use the 243 on occasion. I don't save fur, so that's of no consequence. If I was going to buy a rifle to use on both deer and coyotes, the 243 would be my first choice. The lighter weight 243 bullets shoot like lasers and kill like a lightning bolt. The 243 is also a good deer killer.