Some years ago I went with a 25-06 and a 6x Leupold for my primary mule deer rifle. Also hunt pronghorn with it.
Turns out it's one heck of a coyote rifle as well. I just shoot the same ammo for everything, 115 gr Nosler Ballistic Tips. Never mess with the zero. Just point & shoot. Very deadly. Have taken coyotes out to about 425 yards.
I'd think the .243 would be pretty similar.
Regards, Guy
