20 years ago, I carried a 26" bull barrel .22-250. Got to the point where I did not like the weight. Moved down to .223's in various flavors for 4-5 years. Savage, Ruger, AR15. A 2-3 years ago, I purchased a nice little R700 chambered in .222 I've not taken anything with it yet. It's a super accurate cartridge, mild report and just a joy to shoot.
Bottom line, I'd say shoot the rifle that you're most comfortable shooting, and the most accurate with.