If you can get them to shoot, I think the Nosler Partitions are never a wrong answer in NA.
I have only used them once, but would rely on them on anything. That bear pictured above was completely dead within a few seconds after being hit with a 300gr .375 NP going about 2,520 fps at impact. It smashed through ribs on both sides, turned everything in between into jelly, and flew off into the tundra beyond.
