icedog,
Have you considered a 280-300 grain .366 or .367 inch GCCB in front of that Varget powder, at about 2000FPS??
(Any Western Hemisphere game animal won't care that it was quickly killed by a cheap/hard-hitting cast bullet.)
I suspect that that load would take ANY dangerous game out to 200M, with the possible exception of elephant, which I'll never hunt.
An old boarding school chum of mine has taken SEVERAL moose with his 290 grain homebrewed bullets. = Raney calls his cast handload, "THE BONEBREAKER".
yours, tex
