I don't like too much mid range rise for that very reason. It is all too easy to shoot over or worse, wound an animal in a way that doesn't kill it quickly, when your rifle's zeroed to put the bullets 3 or more inches high at mid range. I remember seeing a nice fallow buck one time with a divot cut out of its backline just above the spine as mute witness of that - he didn't look happy, poor bugger.
With most of my rifles I sight in about 1 1/2" high at 100, so as to have no more than 2" mid-range rise. That will put them on or close to the button at about 200, and so for all practical purposes I can hold right on out to somewhere over 200 (depending on which rifle) without having to think about trajectory. That accounts for the vast majority of the shots I actually take at game. For longer shots I usually have plenty of time to think about trajectory.
For rifles to be used on small game I want less mid-range rise than this.
