From my personal experience, shot placement and the type of bullet have a lot to do with the "destructive" part. My new favorite rifle is a Sako 85 FL 7-08, and thus far I have taken deer past 300 yards with it. I do have access locally to a variety of ammo for it. With that being said having to order for a few other calibers, I would go with a caliber that I can get ammo off the shelf for and not have to order, unless you are going to reload. Lots of new rifles on the market today are way more accurate than the average shooter, pick one you like a go for it.
