I started out in 1973 shooting a .308 with 180gr. Hornady RN bullet, I took my biggest buck with that load. Later switched to 165gr. Sierra GK which worked well, fast forward to the last few years I still use the 165gr. Sierra GK in .30-06 harvested both '019 deer with that combination. I also shoot a .35 Whelen with 200gr. Hornady Inter-lok RN which is accurate and deadly on whitetail, last deer taken with that load was an 8pt. buck. A 100yd. raking shot the bullet was recovered from just under the skin of the farside shoulder. It was perfectly mushroomed and retained 66% of its original weight. .308, .30-06, .35 Whelen have been my go to calibers for deer hunting for the last 58yrs. they always got the job done without a lot of meat loss.