Had a simlar issue a few years ago here. At the time my usual around the property carry gun was an SP 101 3" 357. Killed many a yote out to 50 or 60yds with various HP and FMJ FN loads. Also had an old beater Marlin 25mn 22 mag that always rode on the tractor with me that handled longer range duties. As others have said, goal was to poke a hole in em at least, no so much instant kill. After a season or 2 of this and the yotes still multiplying, got serious about hunting them and equipped myself with a FoxPro e-caller, good predator hunting lights and a damn accurate Tikka 223. Also learned how to trap for yotes and set a bunch of traps. Doing this year round really put a dent in em. Today i still often carry that 3" Sp101, but my equipment rifle is an AR wearing a Vortex Strikefire with a magnifier.
