The one exception I've noticed is very light for caliber medium bore ttsx bullets at high speeds. The 160 ttsx from a .338-06 and the 180 from a .35 Whelen cause a lot of trauma and expend a lot of energy in the animal. I have a picture somewhere of a whitetail doe that I shot through the ribs and the entrance wound looked like an exit wound and there was a bloodshot area about the size of a basketball on the entrance side.
