I've used TSXs, GMXs and E-Tips ranging in caliber from .223 to .375 on dozens of animals from small whitetails to Cape buffalo. I am a big fan and have never experienced what I would consider a failure.
I did have one interesting experience, through: I built a 22-6mmAI with the idea of pushing the 70-grain TSX as fast as possible. I used it on several hogs and deer and, though I recovered all of them, there did not appear to be much expansion or a decent blood trail on any of them. To the best of my knowledge, that bullet was developed for the military's "brown tip" load so clearly penetration was a priority. Great bullet, just not the right bullet for that application. I'm going to try again with lighter TSXs.
My buddy Jeff Johnston did a hog bullet test recently and had great results with the 55-grain TSX, I've experienced the same:
https://youtu.be/59hzyNOUUM8
