Some monos for sure pencil through. Especially those smaller calibers. In general I have noticed animals run longer after being shot with a mono if no bone or the CNS is not hit. Blood trails are often scant as well because the entrance and exit holes are small.
If was not concerned with lead entering my meat supply I would go back to.lead and copper bullets in a heart beat.
Mule Deer has written about this several times on here and I believe in magazine article/s. Hunters have less lead in their bodies than city dwellers who don't hunt. Until the Barnes X bullet came out lead was in all bullets that I know of and we didn't have an epidemic of lead poisoning in hunters or those who ate the meat of animals shot with lead bullets.
