I've kilt them using 223, 25-06, 270, 30-06, 30-30, 257 bee, 300 wsm, 375 h&h, 7.62x39, 250-3000, 22 Hi Power, 300 savage, 303 savage, 50 cal muzzleloader, 45 cal muzzleloader, 44 mag pistol, and by god every one worked. Never lost a deer to any of these. So the answer to your question is whatever you shoot the best with within reasonable reason should work just fine. I have killed texas whitetail Arizona coues whitetail and Arizona muleys with these. YMMV
