There is no doubt that the 22, is superior ballistically, to the 25. The 25 has hung on through the years, due to its perceived advantage in reliability.
The 380's "advantage" over other traditional pocket pistol calibers, really hinges on ammunition choice. For instance, there are 32 ACP loadings that really up that cartridge into the 380 range on most loadings. People think in terms of caliber when they need to be thinking more in terms of load and before either, they need to think in terms of reliability.
