Not so much age for me, but neck/shoulder injuries and time for them to get more bothersome. I downsized to all small/midsized cartridges several years back. 30-30 class stuff is about as large as I can shoot comfortably for more than a handful of rounds these days.

Even just putting 10-15 rounds through my 270 Win had gotten to making me feel like someone had taken a hammer to the back of my head, and I used to be able to sit down and put 50-100 through it no problem when I first got it.

Checking the zero on slug guns was definitely my least favorite time of the year, but the state legislature astonishingly had a fit of good sense and finally legalized some rifles for deer here a couple months ago.