Man, I love the 300 Blackout and the TAC-TX bullets through them, but that's really pushing the envelope for game that large. 😬 I've squeezed 2250-2300fps with the 110s from a 16" barrel, but in both the rifles I've had they shoot better at the more sedate 1950-2000fps range.

You're basically talking 25-35/25 Rem level ballistics. As with those cartridges, it can and has been done, but there are a lot better tools for the job out there.