No experience with the 22-250, but I recently completed a custom #1 that I had rebarreled to 6mm CM.

For the forearm bedding, Apoxie Sculpt is the way to go for the hanger to forearm fit. Very controllable and will not run like other bedding compounds. I got a 1/4 lb kit and after using it to build up and bed the stock and forearm, I still have quite a bit left.

Here I am bedding the hanger to forearm. This is a fiberglass stock. After bedding this area, I bed the area between the receiver and forearm, using one layer of tape to insure that area was free floated. I then used Marine Tex Grey for the remainder, using tape on the barrel to create the free float. If I was doing a wood stock, I would probably just do the hanger spot and just make sure the barrel was free floated.


[Linked Image from i.imgur.com]

The 6mm CM is shooting a consistent 1/2" at 100yards. I have not drilled and tapped the hanger on that rifle yet, but have done so on another #1 in 338Wm that showed improvement.