I read an article once where an Alaskan guide was running through the list of bullet weights he recommended for the caliber of rifle his clients planned on using on their hunts.
Top to bottom on the list, he invariably recommened the heaviest bullet in each caliber, Except in the .338's..he didnt go 225, 250 etc, he recomended the 210 partition and went on to sing the praises of this magical bullet..when that article was written,he was likely referencing .338 win or .340 wby on heavy game and the barnes werent available...I do know thats what I chose to shoot in my .340 and it was fantastic from coyotes to elk, from 75yds to one very lucky 700+yd shot...I think I would agree with Bill N's statement if you feel the likelyhood that bullet trajectory is a likely concern in the country you will be hunting.
