Dunno about 450, but based on the numbers for a 210 NP and my work with the .358, 400 yards should be doable, with some help from a turret or reticle.
My .358 is still packin' enough speed to be "legal" according to Nosler at 400 yards, with the 225-gn NP, and the heavier bullet tracks pretty well in the wind too.
That said- I agree with you, Jordan, in general. Just making the point that with a little work and proper bullet choice fir the job the little fatties can reach out surprisingly far...
