Just to keep things in perspective, though I won't say it can't or shouldn't be done, there aren't as many people who admit to using a 243 on moose as will join the bandwagon......and I know of people who've used 22 rimfires, both long and short, but obviously don't suggest that, so...

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in spite of the fact that plain old CoreLokts and Interlocks can zip right through a moose under the right conditions, remember that they are truly big game animals, and are easily capable of stopping great bullets from more powerful cartridges than the 243.

Bullets pictured, l to r: 250 Speer Grand Slam around 200 yards 340 Wtby, 225 Barnes XFB around 200 yards 340, 170 Rem CoreLokt < 100 yards 30-30 WCF, 160 CT FailSafe >250 yards 7mm-08, 200 Nosler BT around 200 yards 340. All were essentially broadside shots; bullets were shot into the forward lung area which also included varying parts of the shoulder area, some encountering more/bigger bone than others. Every animal died by drowning; drill the lungs!

Sometimes, the air you 'let in'matters less than the air you 'let out'.