Lil Gun was about the best powder that I tried for reduced loads in the 38 Special for late night indoor schützenfests.

CCI Small Rifle Magnum primers gave the best accuracy and seemed to burn the Lil Gun cleaner. This was with 148 grain wad-cutters. 2400 never worked for me in small doses.

To your point about position sensitivity - we tried holding revolvers up and down to keep the powder positioned the same between shots. Never could find the sweet spot on that.