Consider that Hornady's '06 Superformance ammo runs very near 300WM velocity. If you are a handloader, you need to push things pretty hard to do much better.
Net message: an '06 is seriously effective on game. If the Hornady ammo is accurate in your rifle, well, it's even more better.
This from a guy that has hunted 270's for more than 40 years, and so far, not gay.
Also believe that overkill....is just right.