The main limitation, as I see it, is that the .44 mag is NOT a long range cartridge, even in a rifle. Making hits at 200 - 300 yards (or more) would involve a heck of a lot of "Kentucky Windage", and the bullet would not have a lot of energy at those ranges. .
I've knocked over a *lot* of 40 lb steel rams at 200 meters with .44 magnums and it didn't require any Kentucky windage at all. I just knew where to dial the sights in.
