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Alot of talk about big bore crushers here. I've used a few myself over the years. A bunch of 12 gauge slug guns with a bunch of different full bore and saboted slugs. A Marlin .35, a Marlin .44 mag., a Remington 760 .30-06 with 180 gr. RN core lokts. And have found them largely irrelevant to success and of dubious increased effectiveness compared to smaller rounds. Meaning a hit through the lungs with a 12 gauge or a .44 or a .30-06 generally runs aways before it falls and with a shot through the shoulders, spine or head they drop right there. The results with a .30-30 or .243 are pretty much the same. The only advantage the bigger guns MAY provide is a better chance of a heavier blood trail and the ability to reach vitals with an azz shot, which is a shot I won't take anyway.. Neither of those advantages are carved in stone either, depending to a large extent on bullets used and location of hit.