The 300 savage was hugely popular and successful. As usual, something new, something military, something to sell more rifles, came along. The 250 did well, but at a time not far behind black powder and heavy bullets, it was radical.
If there had been enough consumer demand for the two Savage cartridges, Winchester would have made more Models 54 and 70 chambered for them. They didn't, so now 54s and pre-'64 70s chambered in 250-3000 and 300 Savage are among the least common and command high prices from collectors almost without regard to condition.
Prior to the end of WW2, Remington only chambered the Model 81 in 300 Savage and chose not to offer any rifles chambered in 250-3000. Since 1946 Remington has cataloged the Models 722 and 760 in 300 Savage and the 700 Classics for one year runs in both 250-3000 and 300 Savage, plus a few non-cataloged limited runs in 300 Savage for Grice and ??.
Marlin has never offered any rifles chambered for either of the Savage cartridges.
The 243 drove a stake into the heart of the 250-3000 and the 308 did the same to the 300 Savage, just like the 6.5 Creedmoor is likely to do to the 260.
I do occasionally shoot the 250-3000 in one of Larry Koller's Savage 1920s or one of John Barness' Winchester/USRA 70 Lightweight Carbines, but not often.
