Never had the opportunity to moose hunt but one of my buddies recently returned from Canada where he went on his first moose hunt. He was successful. I forgot the details already but it was an average bull and I forgot the range and haven't even seen his pictures yet. However; he did use his 30-378 Weatherby and according to him it was superb which was kind of what I had figured. He's a very good shot under field conditions and I knew he was using (more than) enough gun. His load was a 168 Gr, Barnes TTSX BT with 105 gr. of RL-25 behind it. I know that for sure because I load all his ammo. He has a 300 Weatherby and a 300 RUM also which would have been more than sufficient and even his 280 which I've heard is also an option. If I ever had a moose tag I have a 300 WSM and a decent handload with a 180 gr. Partition that would get the call. Then I could leave my sporterized #4 Lee enfield in 303 Brit. at home and maybe bring my 25-06 as a back-up gun.