I just bought a Remington Model 7 Predator 22-250, and am messing around with it. I've tried several loads, and want to use the 52 grain Speer HP, as I have a bunch of them. I load them using W760, and have gotten some decent groups. Like my Ruger 22-250, it also loves the 40 VMax with Varget. I am out of the VMax's, so I tried some 40 grain Nosler BT's, and they don't seem to shoot as well as the VMax does. The reason for going with a 22-250 over a 223 is velocity, and I am not going to load any "mild" 22-250 loads. I want to push that bullet as fast as possible. I am never going to shoot enough to shoot a barrel out, so no worry there.