My first .22-250, a Winchester M70 push feed Sporter Varmint loved 41.4 gr. of 760 pushing a winchester 55 gr soft point at around 3850 fps. This load is straight from the Hornady manual, 3rd edition.

My current rifle, a Savage 12FV adores IMR4064, enough to drive a 40 gr. Ballistic Tip to 4,000 fps. I reload on a progressive press and tried literally every single ball powder suitable for this cartridge and none was as good IMR4064, so I have a manual powder measure set up on the side and use that to meter charges.

My round count is approaching 5,000 and accuracy is falling off a bit. This barrel won't stabilize most 55 gr. projectiles, so I am thinking about rebarreling with a faster twist.