jrose:

If you are still reading these posts, I have had good results with several powders e.g. IMR 4064, AA 2230, H4895 in my 1x12 twist 22/250.

For bullets, my favorites are the 52 gr. Speer HP and Sierra 40 gr HP.

I have shot the V Maxes and Sierra Blitz Kings, but the first two listed kill very well.