10/22 is really an excellent design, but the ergonomics leave me flat.
90% of rifle ergonomics is the stock design.
Given the shear number and variety of stock designs available for the Ruger 10/22, that is truly a weak critisism..
Beside that, the mag and bolt release are both awkward.
Because of its (excellent) box magazine, the 10/22 is chunky - it's not graceful and slender like an old Mossberg, Remington, Browning or Click-Clack.