I've used the 220 Hornady RN in a 30-40, 30-06 and a 300 H&H. Took a few whitetail and mule deer does with it. Performance was good. Decent expansion, based on the wound evidence and not a lot of meat damage. The deer all died. I load the 220 grain Partition in my 300 H&H and loaned it to a friend to take his caribou. His guns were stolen the day before we left on our hunt so I loaned him my 300 to use. The caribou died quickly.
Those who get drawn for bison in Alaska are required to comply with some bullet weight and energy requirements. This is from the regs:
Rifle/handgun: must fire a 200 grain or larger bullet, which retains at least 2000 foot-pounds of energy at 100 yards. A .30-06 with a 220 grain bullet is about the minimal weapon that meets this specification.
I like heavy for caliber bullets.
