The 220 out of a 30-06 out performs 225's out of a 338-06 or 250's out of a 35 Whelen.
In the history of shooting big animals, it's likely that the biggest were taken with bullets that, by todays standards, were large
WD Bell was probably the most prolific killer of big animals ever, he took over 1000 elephant. The vast majority with a 7X57. The rest with various rifles 30 caliber and smaller.
